Pediatric anesthesia & critical care
Perioperative Transfusion Requirements in Pediatric Patients Receiving Apixaban Prior to Cardiac Surgery With Cardiopulmonary Bypass
Authors' conclusion
Recent apixaban use in children undergoing cardiac surgery was associated with increased intraoperative transfusion of salvaged red cells. The recent use of apixaban does not appreciably increase the perioperative transfusion requirements of pediatric patients undergoing cardiac surgery, including those undergoing emergent procedures.
Study context
- Population
- Children with congenital or acquired heart disease undergoing cardiac surgery with CPB, quaternary children's hospital, 2021 to 2023propensity-matched
- Participants
- 43 vs 172
- Exposure
- Recent apixaban use vs propensity-matched controls
- Apixabann = 43
- Controlsn = 172reference
- Outcome
- Perioperative transfusion
Methodological detailspropensity-matched, single-centre, 81% of procedures urgent or emergent; 30% reoperative sternotomies
- Propensity-matched
- Single-centre
- 81% of procedures urgent or emergent; 30% reoperative sternotomies
Main finding
As reported in the abstract
- Intraoperative red cell salvage volume: 20.6 (Apixaban) vs 12.9 (Controls) mL/kg
- p = 0.041
Observational data: associations, not effects.
Further findings
Emergent reexploration or death within 7 days
- No statistically significant difference between the 2 groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Perioperative Transfusion Requirements in Pediatric Patients Receiving Apixaban Prior to Cardiac Surgery With Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. Published 26 December 2025. doi:10.
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