Perioperative medicine & outcomes
Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial
Primary resultResult — go to the resultOdds ratio 0.84 95% CI 0.40–1.75Authors' conclusion
Personalised intraoperative blood pressure management maintaining preoperative baseline MAP neither reduced the incidence of the composite primary outcome neurocognitive disorders between postoperative days 3 and 7 nor the incidences of the components of the composite primary outcome-delayed neurocognitive recovery and delirium-compared to routine blood pressure management in patients having major noncardiac surgery.
Study context
- Population
- Elective major noncardiac surgery patients
- Participants
- 328 patients
- Comparison
- Personalised vs routine intraoperative BP management
- Primary endpoint
- Incidence of neurocognitive disorders:
- Delayed neurocognitive recovery
- Delirium
- Follow-up
- Between postoperative days 3 and 7
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Odds ratio
0.84
95% CI 0.40–1.75
P = 0.622
Events by treatment group
Personalised vs Routine
OR 0.84 (95% CI 0.40–1.75); P = 0.622
Further findings
| Outcome | Personalised | Routine | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Delayed neurocognitive recovery | 12% | 12% | 0.99 (0.45–2.17) | P = 0.983 | |
| Delirium | 1% | 3% | 0.50 (0.04–3.53) | P = 0.684 | |
| 0.050.21520Odds ratio (log scale) |
- Delayed neurocognitive recovery: 17 of 146 vs 17 of 145
- Delirium: 2 of 157 vs 4 of 158
Original publication
Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial. BJA Open. Published 1 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →