Pediatric anesthesia & critical care
Pertussis infection in critically ill infants: meta-analysis and validation of a mortality score
Authors' conclusion
This meta-analysis identified a simple yet effective score to assess the severity of pertussis infection in infants admitted to PICU.
Study context
- Population
- Critically ill infants with pertussis admitted to Pediatric Intensive Care Unit (PICU)
- Participants
- 2,725 infants · 17 studies
- Outcome
- Mortality before discharge from the PICU
Methodological detailsREML random-effects model, monocentric validation cohort, Data analysis between June and August 2024; validation cohort admitted January 1996 to December 2020
- REML random-effects model
- Monocentric validation cohort
- Data analysis between June and August 2024; validation cohort admitted January 1996 to December 2020
Pooled result
As reported in the abstract
Pooled mortality incidence
Pooled mortality incidence
19%
95% CI 12–26; I2 = 96
Further pooled results
Pooled prevalence of organ support
- Mechanical ventilation
- 55% (95% CI: 40-70; I2 = 98)
- CRRT
- 15% (95% CI: 3-27; I2 = 95)
- ECMO
- 8% (95% CI: 3-12; I2 = 93)
Validation cohort (n = 83; median age 45 days, IQR 30-55): mortality
- Mortality rate
- 12%
- Meta-analysis risk factors significantly associated with non-survival in the cohort
Mortality prediction score (age < 30 days, heart rate > 200/min, white blood cell (WBC) > 30 G/l)
- AUC
- 0.92 (95% CI: 0.86-0.99)
Original publication
Pertussis infection in critically ill infants: meta-analysis and validation of a mortality score. Crit Care. Published 10 February 2025. doi:10.
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