Pharmacological agents for prevention of pruritus in women undergoing Caesarean delivery with neuraxial morphine: a systematic review and Bayesian network meta-analysis
Authors' conclusion
Our analysis found several interventions to be effective in reducing the incidence of pruritus.
Study context
- Population
- Adult women undergoing Caesarean delivery with intrathecal or epidural single-shot morphine14 interventions incl
- Participants
- 6,185 women
- Comparison
- Pharmacological agents vs placebo for prevention of pruritus
- Outcome
- Incidence of pruritus
Methodological detailsBayesian model network meta-analysis, Databases searched up to January 2022
- Bayesian model network meta-analysis
- Databases searched up to January 2022
Pooled result
As reported in the abstract
- Propofol, opioid agonist-antagonists (neuraxial), opioid antagonists, opioid agonist-antagonists (systemic) and serotonin antagonists 'definitely superior' to placebo
- Only the five interventions judged superior are named; the other interventions of the 14 are not named
Further pooled results
Severe pruritus (warranting additional treatment)
- Dopamine antagonists (neuraxial) and systemic and neuraxial opioid agonist-antagonists 'definitely superior' to placebo
- 14 interventions incl. placebo, 4489 patients
Original publication
Pharmacological agents for prevention of pruritus in women undergoing Caesarean delivery with neuraxial morphine: a systematic review and Bayesian network meta-analysis. Br J Anaesth. Published 14 July 2023. doi:10.
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