Pediatric anesthesia & critical care
Population pharmacokinetic-pharmacodynamic analysis and dose optimisation of ciprofol in paediatric anaesthesia
Authors' conclusion
A ciprofol induction dose of 0.6 mg kg-1 followed by a weight-stratified maintenance infusion of 1.0-1.4 mg kg-1 h-1 is recommended for paediatric anaesthesia.
Study context
- Population
- Paediatric patients (0.08–15 yr; weight 4.2–71.0 kg) undergoing cardiac or thoracic surgery
- Participants
- 88 patients
- Comparison
- Ciprofol induction 0.6 vs 0.9 mg kg-1
- Outcome
- PopPK/PD model and dose recommendations
Methodological detailsopportunistic blood sampling, effect compartment model, simulation-based dosing
- Opportunistic blood sampling
- Effect compartment model
- Simulation-based dosing
Main finding
As reported in the abstract
Recommended induction dose
0.6 mg kg-1
Recommended maintenance (target BIS 40-60), weight 0-5 kg
1.4 mg kg-1 h-1
Recommended maintenance, weight 5-30 kg
1.2 mg kg-1 h-1
Recommended maintenance, weight >30 kg
1.0 mg kg-1 h-1
Original publication
Population pharmacokinetic-pharmacodynamic analysis and dose optimisation of ciprofol in paediatric anaesthesia. Br J Anaesth. Published 2 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →