Postcesarean Analgesia With Epidural Morphine After Epidural 2-Chloroprocaine: A Randomized Noninferiority Trial
Authors' conclusion
While designed as an exploratory study, initial epidural dosing with 3% CP and beginning subsequent redosing with LEB within 30 minutes of the initial CP bolus provided noninferior postcesarean analgesia with epidural morphine compared to initial epidural dosing and redosing with LEB.
Study context
- Population
- Term parturients scheduled for nonemergent, unscheduled cesarean delivery with preexisting labor epidural cathetersanalyzed
- Participants
- 40 participants
- Comparison
- CP vs LEB
- CPn = 20
- LEBn = 20reference
- Primary endpoint
- Difference between groups in total opioid use in first 24 h after epidural morphine (noninferiority margin 10 oral MME)
- Follow-up
- 24 hours
Methodological detailsexploratory, single-blinded, noninferiority
- Exploratory
- Single-blinded
- Noninferiority
Primary result
As reported in the abstract
Total opioid consumption in first 24 h after epidural morphine (oral MME)
Secondary outcomes
Time to first opioid request
- No treatment effect on time to first opioid request
Pain scores · 4, 8, 12, and 24 hours after epidural morphine
- No statistically significant differences in pain scores at all time points
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Postcesarean Analgesia With Epidural Morphine After Epidural 2-Chloroprocaine: A Randomized Noninferiority Trial. Anesth Analg. Published 3 June 2022. doi:10.
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