Perioperative medicine & outcomes
Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia: A Randomized Controlled Trial
An erratum to this article was published (Anesthesiology, 1 Apr 2023 ↗)
Primary resultResult — go to the resultOdds ratio 0.42 95% CI 0.201–0.86Authors' conclusion
Dexmedetomidine showed a lower incidence of postoperative delirium than propofol in healthy older adults undergoing lower extremity orthopedic surgery.
Study context
- Population
- Patients aged 65 yr or older scheduled for elective lower extremity orthopedic surgery with spinal anaesthesia, June 2017–October 2021732 in ITT analyses
- Participants
- 748 patients
- Comparison
- Intraoperative dexmedetomidine vs propofol sedation
- Primary endpoint
- Postoperative delirium incidence (confusion assessment method)
- Follow-up
- First three postoperative days
Methodological detailsdouble-blinded
- Double-blinded
Primary result
As reported in the abstract
Odds ratio
0.42
95% CI 0.201–0.86
P = 0.036
Events by treatment group
Dexmedetomidine vs Propofol
OR 0.42 (95% CI 0.201–0.86); P = 0.036
Secondary outcomes
MAP during sedation · higher with dexmedetomidine
P < 0.001
MAP in PACU · lower with dexmedetomidine
P < 0.001
Heart rate during sedation
Heart rate in PACU · lower with dexmedetomidine
P < 0.001
Heart rate during sedation
- Lower heart rate with dexmedetomidine
Original publication
Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia: A Randomized Controlled Trial. Anesthesiology. Published 19 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →