Postoperative Outcomes in Elderly Patients Undergoing Cardiac Surgery With Preoperative Cognitive Impairment: A Systematic Review and Meta-Analysis
Pooled result · DeliriumResult — go to the resultOdds ratio 8.35 95% CI 4.25–16.38Authors' conclusion
In older patients undergoing cardiac surgery, cognitive impairment was associated with an 8-fold increased risk of delirium, a 5% increase in absolute risk of major postoperative bleeding, and an increase in hospital and ICU LOS by approximately 0.4 days.
Study context
- Population
- Cardiac surgery patients ≥60 years of age
- Participants
- 62,179 patients · 16 studies
- Comparison
- Cognitive impairment vs No cognitive impairment
- Outcome
- Delirium
Methodological detailsrandom-effects model, trial sequential analysis
- Random-effects model
- Trial sequential analysis
Pooled result
As reported in the abstract
Odds ratio
8.35
95% CI 4.25–16.38
P < 0.00001
By group
Cognitive impairment vs No cognitive impairment
OR 8.35 (95% CI 4.25–16.38); P < 0.00001
Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| Hospital LOSI 2 , 22% | 0.36 (0.20–0.51) | P < 0.00001 | |
| ICU LOSI 2 , 70% | 0.39 (0.09–0.68) | P = 0.01 | |
| −0.500.51Difference (linear scale) |
30-day mortality
- No significant association
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Postoperative Outcomes in Elderly Patients Undergoing Cardiac Surgery With Preoperative Cognitive Impairment: A Systematic Review and Meta-Analysis. Anesth Analg. Published 11 January 2023. doi:10.
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