Pediatric anesthesia & critical care
Postoperative recovery in preschool‐aged children: A secondary analysis of a randomized controlled trial comparing premedication with midazolam, clonidine, and dexmedetomidine
Authors' conclusion
No statistical difference was observed in the postoperative recovery times between the premedication regimens. Compared with midazolam, dexmedetomidine was favorable in reducing both emergence delirium and pain in the postoperative care unit, and both clonidine and dexmedetomidine reduced anxiety in the postoperative care unit.
Study context
- Population
- Children aged 2–6 years scheduled for ear, nose and throat surgery under TIVA (propofol-remifentanil)82 analysed
- Participants
- 90 children
- Comparison
- Midazolam vs Clonidine vs Dexmedetomidine
- Primary endpoint
- Time to readiness for discharge from the postoperative care unit
Methodological detailsprespecified secondary analysis, double-blinded
- Prespecified secondary analysis
- Double-blinded
Primary result
As reported in the abstract
Time to readiness for discharge
Further findings
Postoperative sedation
- No differences vs midazolam
- Logistic regression, mixed model, repeated measures
Emergence delirium
- Less in the dexmedetomidine group vs midazolam
Pain
- Less in the dexmedetomidine group vs midazolam
Anxiety
- Less in both clonidine and dexmedetomidine groups vs midazolam
Original publication
Postoperative recovery in preschool‐aged children: A secondary analysis of a randomized controlled trial comparing premedication with midazolam, clonidine, and dexmedetomidine. Paediatr Anaesth. Published 1 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →