Perioperative medicine & outcomes
Prediction of Acute Myocardial Injury in Noncardiac Surgery in Patients at Risk for Major Adverse Cardiovascular and Cerebrovascular Events: A Multivariable Risk Model
Authors' conclusion
Baseline determination of cardiac biomarkers in patients at risk for MACCE shortly before intermediate- or high-risk noncardiac surgery helps identify those with the highest risk for acute myocardial injury.
Study context
- Population
- Consecutive adults (≥45 years) at risk for MACCE scheduled for intermediate-to-high-risk noncardiac surgery
- Participants
- 732 adults
- Exposure
- Elevated vs normal baseline high-sensitivity troponin T (hsTnT) (≥14 ng/L) as predictor of acute myocardial injury
- Outcome
- Acute myocardial injury
Methodological detailssingle-centre, consecutive enrolment, multivariable risk model, decision curve analysis
- Single-centre
- Consecutive enrolment
- Multivariable risk model
- Decision curve analysis
Main finding
As reported in the abstract
- Acute myocardial injury incidence: 161 patients
- 22%
- Elevated baseline hsTnT associated with acute myocardial injury, OR
- 12.08 (95% CI, 7.78-19.42)
- Elevated baseline hsTnT among patients with acute myocardial injury
- 84%
- C-statistic of risk model
- 77% (95% CI, 0.73-0.81)
- Net benefit of the model began at risk threshold
- 7%
Observational data: associations, not effects.
Further findings
Baseline biomarker elevation
- Elevated hsTnT
- 42.1%
- Elevated NT-proBNP
- 37.3%
Original publication
Prediction of Acute Myocardial Injury in Noncardiac Surgery in Patients at Risk for Major Adverse Cardiovascular and Cerebrovascular Events: A Multivariable Risk Model. Anesth Analg. Published 12 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →