Pediatric anesthesia & critical care
Prediction of good neurological outcome after return of circulation following paediatric cardiac arrest: A systematic review and meta-analysis
Authors' conclusion
Clinical examination, electrophysiology, neuroimaging or blood-biomarkers as individual tests can predict good neurological outcome after cardiac arrest in children. However, evidence is often low quality and studies are heterogeneous.
Study context
- Population
- Children within 14 days of return of circulation after out- or in-hospital cardiac arrest
- Participants
- 2,974 children · 35 studies
- Outcome
- Good neurological outcome (no, mild, moderate disability or minimal change from baseline): sensitivity and FPR of each predictor
Methodological detailsAll studies had moderate to high risk of bias (QUIPS)
- All studies had moderate to high risk of bias (QUIPS)
Pooled result
As reported in the abstract
Predictors of good neurological outcome
- False positive rates (FPR) <30% with moderate (50-75%) or high (>75%) sensitivity: bilateral reactive pupillary light response within 12 h; GCS motor ≥4 at 6 h; bilateral somatosensory evoked potentials at 24-72 h; sleep spindles and continuous cortical activity on EEG within 24 h; normal brain MRI at 4-6d
- FPR <30% with low (<50%) sensitivity: early (≤12 h) normal lactate (<2mmol/L) or normal s100b, NSE or MBP
Original publication
Prediction of good neurological outcome after return of circulation following paediatric cardiac arrest: A systematic review and meta-analysis. Resuscitation. Published 30 December 2024. doi:10.
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