Perioperative medicine & outcomes
Predictive Value of a Novel Frailty Index for Cardiovascular Outcomes after Major Noncardiac Surgery: A Prospective Cohort Study
Authors' conclusion
A frailty index derived from preoperative multidimensional geriatric assessment can improve cardiovascular risk prediction before noncardiac surgery, primarily by improving risk estimation for patients who will not develop postoperative cardiovascular events.
Study context
- Population
- Older patients undergoing elective major noncardiac surgery
- Participants
- 1,808 patients
- Exposure
- FI-PGA added to clinical prediction models
- Outcome
- Any cardiovascular events
- Follow-up
- 30 days after surgery
Main finding
As reported in the abstract
Any CV events (primary outcome) · 30 days
FI-PGA, per 0.1-point incrementOdds ratio (95% CI)
Adjusted for clinical predictors
1.56(1.33–1.82)
Adjusted for clinical predictors plus preoperative NT-proBNP
1.37(1.16–1.61)
Per 0.1-point increment, as printed
- Patients with primary outcome
- 316 (17.5%)
Observational data: associations, not effects.
Further findings
Added predictive value of FI-PGA
- Significantly improved model fit and provided new predictive information
- Net reclassification improved risk estimation for patients without postoperative CV events, not for those with events
- Decision curves: models containing FI-PGA achieved higher net benefit
Clinical Frailty Scale
- Improved model performance, although added predictive values appeared lower
Original publication
Predictive Value of a Novel Frailty Index for Cardiovascular Outcomes after Major Noncardiac Surgery: A Prospective Cohort Study. Anesthesiology. Published 24 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →