Cardiac arrest & resuscitation
Predictive value of soluble CD59 for poor 28-day neurological prognosis and all-cause mortality in patients after cardiopulmonary resuscitation: a prospective observatory study
Authors' conclusion
The elevated serum level of sCD59 was positively correlated with disease severity after ROSC. Moreover, serum sCD59 could have good predictive values for the poor 28-day neurological prognosis and all-cause mortality in patients after ROSC.
Study context
- Population
- Patients after restoration of spontaneous circulation (ROSC) following CPR68 patients after ROSC
- Participants
- 23 / 45 / 20
- Exposure
- Survivors vs non-survivors at 28 days after ROSC; healthy volunteers as controls
- Survivorsn = 23reference
- Non-survivorsn = 45
- Controlsn = 20
- Outcome
- Predictive value of serum sCD59 for poor neurological prognosis (cerebral performance category 3-5) and all-cause mortality
- Follow-up
- 28 days
Main finding
As reported in the abstract
Prediction by serum sCD59 on day 3 after ROSC
AUC of day-3 sCD59 for poor 28-day neurological prognosis
0.862
95% CI 0.678–0.960
AUC of day-3 sCD59 for 28-day all-cause mortality
0.891
95% CI 0.769–0.962
Observational data: associations, not effects.
Further findings
Serum complement components, inflammatory mediators and neurological damage biomarkers · first week after ROSC
- sCD59, sC5b-9, C5a, C3a, C3b, C1q, MBL, Bb, tumor necrosis factor (TNF)-α, IL-6, neuron-specific enolase (NSE) and S100β significantly elevated after ROSC vs healthy volunteers; significantly higher in non-survivors vs survivors except C1q and MBL
Correlations of serum sCD59
- Positively correlated with sC5b-9, TNF-α, IL-6, NSE, S100β, SOFA and APACHE II scores
Original publication
Predictive value of soluble CD59 for poor 28-day neurological prognosis and all-cause mortality in patients after cardiopulmonary resuscitation: a prospective observatory study. J Intensive Care. Published 2 February 2023. doi:10.
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