Neuroanesthesia & neurocritical care
Prehospital Postintubation Hypotension and Survival in Severe Traumatic Brain Injury
Main finding · 30-day mortalityResult — go to the resultAdjusted odds ratio 1.70 95% CI 1.01–2.86Authors' conclusion
In this cohort study of patients with severe TBI who received prehospital rapid sequence induction, postintubation hypotension was associated with increased 30-day mortality.
Study context
- Population
- Adults (≥16 years) with trauma and severe traumatic brain injury (TBI) (Head Abbreviated Injury Scale ≥3) receiving prehospital RSI by helicopter EMS, East of England Trauma Network, 2015–2022included in final analysis
- Participants
- 555 adults
- Exposure
- Postintubation hypotension vs no postintubation hypotension
- Hypotensionn = 106
- Nonhypotensionn = 449reference
- Outcome
- Mortality
- Follow-up
- 30 days
Methodological detailsmulticentre, observational
- Multicentre
- Observational
Main finding
30-day mortality
Adjusted odds ratio
1.70
95% CI 1.01–2.86
P = 0.04
Events by group
Hypotension vs Nonhypotension
aOR 1.70 (95% CI 1.01–2.86); P = 0.04
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| 30-day mortality, isolated severe TBI (subgroup) | 13.55 (3.65–61.66) | P < 0.001 | |
| 0.050.21520Adjusted odds ratio (log scale) |
- 30-day mortality, isolated severe TBI (subgroup): adjusted for confounders (eg, age, GCS, Injury Severity Score)
Original publication
Prehospital Postintubation Hypotension and Survival in Severe Traumatic Brain Injury. JAMA Netw Open. Published 3 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →