Perioperative medicine & outcomes
Prevention of Postoperative Cognitive Dysfunction by Minocycline in Elderly Patients after Total Knee Arthroplasty: A Randomized, Double-blind, Placebo-controlled Clinical Trial
Primary result · POCDResult — go to the resultOdds ratio 2.22 95% CI 0.64–7.65Authors' conclusion
Minocycline is likely to have no preventive effect on postoperative cognitive dysfunction.
Study context
- Population
- Patients aged >60 yr undergoing total knee arthroplasty under GA30 healthy volunteers as controls
- Participants
- 100 vs 102
- Comparison
- Minocycline vs Placebo
- Minocyclinen = 100
- Placebon = 102reference
- Primary endpoint
- Incidence of POCD (4-test neurocognitive battery, accounting for learning effect)
- Follow-up
- 1 week and 3 months after surgery
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
POCD · 1 week
Odds ratio
2.22
95% CI 0.64–7.65
P = 0.240
Events by treatment group
Minocycline vs Placebo
OR 2.22 (95% CI 0.64–7.65); P = 0.240
As reported in the abstract
Secondary outcomes
| Outcome | Minocycline | Placebo | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| POCD · 3 monthsMissing data corrected by multiple imputation | 17.0% | 16.1% | 1.07 (0.49–2.32) | P = 0.889 | |
| 0.512Odds ratio (log scale) |
- POCD: 15.3 of 90 vs 15.3 of 95
Postoperative delirium and postoperative pain
- No differences between the two groups
Original publication
Prevention of Postoperative Cognitive Dysfunction by Minocycline in Elderly Patients after Total Knee Arthroplasty: A Randomized, Double-blind, Placebo-controlled Clinical Trial. Anesthesiology. Published 13 December 2022. doi:10.
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