ICU sedation, delirium & recovery
Procedural sedative effect of remimazolam in intensive care unit (ICU) patients on invasive mechanical ventilation: a randomised, prospective study
Authors' conclusion
Current evidence suggests that remimazolam is a safe sedative that is particularly well suited for patients with haemodynamic instability.
Study context
- Population
- Intubated ICU patients on invasive mechanical ventilationsingle centre
- Participants
- 80 patients
- Comparison
- Remimazolam vs Propofol
- Remimazolamn = 40
- Propofoln = 40reference
- Primary endpoint
- MAP
- Follow-up
- Days 4 and 7
Methodological detailssingle-centre, prospective
- Single-centre
- Prospective
Primary result
As reported in the abstract
Day 4
- Mean arterial pressure (MAP), control group vs. experimental group (mean ± SD), significantly differed
- 85.23 ± 11.24 vs. 94.36 ± 13.18
- P
- P = 0.021
Further findings
Dyslipidaemia
Delirium
| Outcome | P value |
|---|---|
| ∆AST · Day 7Significantly lower in remimazolam group than control group | P = 0.023 |
| Triglyceride (TG) levels · Days 4 and 7Significant differences | P = 0.020 |
| ∆LDL · Day 7Significant difference | P = 0.027 |
- Dyslipidaemia: n = 40 per group
- Delirium: n = 40 per group
MAP · Day 7
- MAP, control group vs. experimental group (mean ± SD), significantly differed
- 83.55 ± 8.94 vs. 92.66 ± 7.02
- P
- P = 0.023
Safety
Dyslipidaemia
Delirium
Original publication
Procedural sedative effect of remimazolam in ICU patients on invasive mechanical ventilation: a randomised, prospective study. Ann Intensive Care. Published 14 January 2025. doi:10.
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