Prognosis of critically ill patients with severe acute kidney injury and high circulating dipeptidyl peptidase 3: a post hoc analysis of the AKIKI 2 trial
Primary result · 28-day mortalityResult — go to the resultHazard ratio 1.95 95% CI 1.37–2.87Authors' conclusion
In critically ill patients with severe AKI, a high cDPP3 concentration at diagnosis is associated with increased short-term mortality and prolonged dependence on organ support.
Study context
- Population
- ICU patients with severe acute kidney injury (AKI) (KDIGO stage 3) receiving (or having received) invasive mechanical ventilation and/or vasopressor support, with blood samples at inclusion
- Participants
- 287 patients
- Comparison
- High vs low circulating DPP3
- High cDPP3n = 143
- Primary endpoint
- 28-day mortality
- Follow-up
- 28 days
Methodological detailspost hoc analysis, predefined cutoff
- Post hoc analysis
- Predefined cutoff
Primary result
As reported in the abstract
Hazard ratio
1.95
95% CI 1.37–2.87
P < 0.001
High cDPP3 vs Low cDPP3
HR 1.95 (95% CI 1.37–2.87); P < 0.001
Secondary outcomes
| Outcome | Mean difference (95% CI) | P value |
|---|---|---|
| Days alive without vasopressorsHigh cDPP3 vs Low cDPP3 | - 5.59 (- 8.29 to - 2.78) | P < 0.001 |
| Days alive without invasive mechanical ventilationHigh cDPP3 vs Low cDPP3 | - 6.23 (- 8.89 to - 3.36) | P < 0.001 |
| Days alive without RRTHigh cDPP3 vs Low cDPP3 | - 6.35 (- 9.14 to - 3.26) | P < 0.001 |
Organ support-free days, adjusted for baseline severity
- Association remained significant after adjustment
Original publication
Prognosis of critically ill patients with severe acute kidney injury and high circulating dipeptidyl peptidase 3: a post hoc analysis of the AKIKI 2 trial. Crit Care. Published 3 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →