Prognostic factors for chronic post‐surgical pain after lung and pleural surgery: a systematic review with meta‐analysis, meta‐regression and trial sequential analysis
Authors' conclusion
We thus identified actionable factors which can be addressed to attempt to reduce the risk of chronic post-surgical pain after lung surgery.
Study context
- Population
- Patients undergoing lung or pleural surgery56 studies
- Comparison
- Prognostic factors for chronic post-surgical pain
- Outcome
- Chronic post-surgical pain (prognostic factors)
Methodological detailsmeta-regression, trial sequential analysis, GRADE certainty assessment
- Meta-regression
- Trial sequential analysis
- GRADE certainty assessment
Pooled result
As reported in the abstract
Prognostic factors for chronic post-surgical pain (45 identified, 16 pooled)
MD (95% CI)P value
Higher postoperative pain intensity (day 1, 0-10 score)increased risk; low certainty
1.29(0.62–1.95)
P < 0.001Odds ratio (95% CI)P value
Pre-operative painincreased risk; high certainty
2.86(1.94–4.21)
P < 0.001Intercostal nerve blockdecreased risk; moderate certainty
0.76(0.61–0.95)
P = 0.018Video-assisted thoracic surgerydecreased risk; high certainty
0.54(0.43–0.66)
P < 0.001MD, minutes (95% CI)P value
Longer surgery durationincreased risk; moderate certainty
12.07(4.99–19.16)
P < 0.001Further pooled results
Age and sex
- Age had no significant effect; not enough evidence to conclude on sex
Meta-regression of study covariates
- No significant effects of any study covariate on the significant prognostic factors
Original publication
Prognostic factors for chronic post‐surgical pain after lung and pleural surgery: a systematic review with meta‐analysis, meta‐regression and trial sequential analysis. Anaesthesia. Published 24 April 2023. doi:10.
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