Pediatric anesthesia & critical care
Prolonged opioid use after surgery in children, adolescents, and young adults: a systematic review
Authors' conclusion
We identified four patient-level predictors of POUS in this systematic review.
Study context
- Population
- Children, adolescents and young adults undergoing any type of surgical procedure
- Participants
- 1,576,515 children · 17 studies
- Outcome
- Rate of prolonged opioid use after surgery (POUS)
Methodological detailsbest-evidence synthesis, risk of bias assessed with adapted SIGN checklist for cohort studies, Databases searched: MEDLINE, Embase, CINAHL
- Best-evidence synthesis
- Risk of bias assessed with adapted SIGN checklist for cohort studies
- Databases searched: MEDLINE, Embase, CINAHL
Pooled result
As reported in the abstract
Rate of POUS
Estimated median reported rate of POUS
4.5%
Further pooled results
Patient-level risk factors for POUS
- Older age, female sex, history of chronic pain and preoperative opioid use associated with POUS
Original publication
Prolonged opioid use after surgery in children, adolescents, and young adults: a systematic review. Can J Anaesth. Published 24 March 2025. doi:10.
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