Pediatric anesthesia & critical care
A Prospective Observational Study of Intraoperative Regional Cerebral Desaturation and Negative Postoperative Behavioural Changes After Non‐Cardiac Paediatric Surgery
Main finding · crSO2 reduction by NPOBC statusResult — go to the resultOdds ratio 1.25 CI 0.71–2.20Authors' conclusion
Regional cerebral desaturation and negative postoperative behaviour may be less common than previously reported in young children undergoing uneventful general anaesthesia. We could not corroborate the strong association between these entities reported previously.
Study context
- Population
- Healthy children aged 2–6 years undergoing routine non-cardiac surgery under GAenrolled
- Participants
- 180 children
- Exposure
- Negative postoperative behaviour changes (NPOBC) vs No NPOBC
- Outcome
- NPOBC (Post Hospitalization Behavior Questionnaire, parent-reported)
- Follow-up
- POD 7
Methodological detailsobservational
- Observational
Main finding
crSO2 reduction by NPOBC status · Day 7
Odds ratio
1.25
CI 0.71–2.20
P = 0.46
Events by group
Intraoperative crSO2 reduction
OR 1.25 (CI 0.71–2.20); P = 0.46
As reported in the abstract
Observational data: associations, not effects.
Further findings
Older age and NPOBC
| OR (CI) | P value | ||
|---|---|---|---|
| Older age | 0.39 (0.15–0.99) | P = 0.048 | |
| 0.10.31310Odds ratio (log scale) |
Incidence of NPOBC
- Day 7
- 13%
- Day 30
- 15%
Correlation of crSO2 AUC with NPOBC
- No statistically significant correlation (r)
- 0.11
Original publication
A Prospective Observational Study of Intraoperative Regional Cerebral Desaturation and Negative Postoperative Behavioural Changes After Non‐Cardiac Paediatric Surgery. Acta Anaesthesiol Scand. Published 15 October 2025. doi:10.
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