Proton pump inhibitors for gastrointestinal bleeding prophylaxis in critically ill patients: A systematic review protocol

Wang, Y; Heels-Ansdell, D; Ge, L; Parpia, S; Ibrahim, Q; Cook, D; Deane, A; Lauzier, F; Hammond, N; Møller, MH; Krag, M; Perner, A; Guyatt, GH

doi:10.1111/aas.14426

ICU sedation, delirium & recovery

Proton pump inhibitors for gastrointestinal bleeding prophylaxis in critically ill patients: A systematic review protocol

Acta Anaesthesiol ScandPublished 5 Apr 2024Systematic review and meta-analysis of randomised trials

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Study context

Population: Adults in the intensive care unit (ICU) (critically ill)

Planned comparison: Proton pump inhibitors (PPIs) vs placebo or no prophylaxis

Methodological detailsprotocol, random-effects model, GRADE, Planned subgroup analysis: impact of PPIs on mortality in more vs less severely ill patients

Protocol
Random-effects model
GRADE
Planned subgroup analysis: impact of PPIs on mortality in more vs less severely ill patients

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Proton pump inhibitors for gastrointestinal bleeding prophylaxis in critically ill patients: A systematic review protocol. Acta Anaesthesiol Scand. Published 5 April 2024. doi:10.1111/aas.14426

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