Perioperative medicine & outcomes
Pulmonary complications with individualised vs. fixed positive end‐expiratory pressure in older patients recovering from lung cancer surgery: a randomised trial
Primary resultResult — go to the resultRelative risk 1.09 95% CI 0.79–1.52Authors' conclusion
Electrical impedance tomography-guided individualised positive end-expiratory pressure reduced driving pressures and improved intra-operative oxygenation but did not decrease the incidence of postoperative pulmonary complications in older adults undergoing lung cancer surgery.
Study context
- Population
- Older patients (age ≥ 60 years) undergoing lung cancer surgery
- Participants
- 400 patients
- Comparison
- Individualised PEEP vs fixed PEEP of 5 cmH2O
- PEEPINDn = 195
- PEEP5n = 197reference
- Primary endpoint
- Incidence of postoperative pulmonary complications
Primary result
As reported in the abstract
Relative risk
1.09
95% CI 0.79–1.52
P = 0.60
Events by treatment group
Secondary outcomes
Driving pressure during OLV · lower in PEEPIND
P < 0.001
Range PEEPIND 4-23 · PEEP5 7-24
Driving pressure during two-lung ventilation · lower in PEEPIND
P < 0.001
Range PEEPIND 4-26 · PEEP5 5-26
Oxygenation index during OLV · higher in PEEPIND
P < 0.001
Range PEEPIND 6.7-55.9 · PEEP5 8.8-58.9
Individualised PEEP level during OLV
- Median (IQR [range]) individualised PEEP during OLV
- 11 (9-11 [3-13]) cmH2O
Individualised PEEP level during two-lung ventilation
- Median (IQR [range]) individualised PEEP during two-lung ventilation
- 9 (7-9 [3-13]) cmH2O
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →