Cardiac arrest & resuscitation
Pulse Oximetry and Arterial Blood Gas Oxygen Saturation Discrepancies and Mortality in Extracorporeal Cardiopulmonary Resuscitation Patients: An Extracorporeal Life Support Organization Registry Analysis
Main finding · In-hospital mortalityResult — go to the resultAdjusted odds ratio 1.39 95% CI 1.13–1.71Authors' conclusion
Sp o2 -Sa o2 greater than or equal to 4% in the first 24 hours after ECPR is associated with increased risk of mortality, potentially due to unrecognized hypoxemia, irrespective of race/ethnicity.
Study context
- Population
- Adults (≥18 yr) receiving extracorporeal cardiopulmonary resuscitation (ECPR) (first run only), Extracorporeal Life Support Organization Registry, 496 extracorporeal membrane oxygenation (ECMO) centers, 2018–2024
- Participants
- 3,970 adults · 496 ECMO centers
- Exposure
- SpO2-SaO2 discrepancy ≥4% vs <4% at 24 hours of ECMO support
- Sp o2 -Sa o2 greater than or equal to 4%n = 634
- Sp o2 -Sa o2 less than 4%n = 3,336reference
- Outcome
- In-hospital mortality
Methodological detailsmulticentre registry, Median ECMO duration 4 days (IQR 2-7 d)
- Multicentre registry
- Median ECMO duration 4 days (IQR 2-7 d)
Main finding
As reported in the abstract
Adjusted odds ratio
1.39
95% CI 1.13–1.71
Events by group
SpO2-SaO2 ≥4% vs SpO2-SaO2 <4%
aOR 1.39 (95% CI 1.13–1.71)
Observational data: associations, not effects.
Further findings
Serum lactate
P = 0.0017
Other risk factors for mortality (multivariable)
| aOR (95% CI) | ||
|---|---|---|
| Acute brain injury | 5.81 (4.70–7.20) | |
| Hyperoxemia ≥300 mm Hg | 1.93 (1.53–2.43) | |
| Hyperoxemia 200-299 mm Hg | 1.76 (1.37–2.25) | |
| Gastrointestinal hemorrhage | 1.69 (1.42–2.00) | |
| RRT | 1.48 (1.03–2.11) | |
| Hypoxemia <60 mm Hg | 1.45 (1.00–2.10) | |
| Older age | 1.19 (1.13–1.26) | |
| Higher lactate | 1.17 (1.13–1.20) | |
| 0.10.31310Adjusted odds ratio (log scale) |
- Race/ethnicity not associated with higher mortality
Overall mortality
- Overall mortality
- 60% ( n = 2391)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Pulse Oximetry and Arterial Blood Gas Oxygen Saturation Discrepancies and Mortality in Extracorporeal Cardiopulmonary Resuscitation Patients: An Extracorporeal Life Support Organization Registry Analysis. Crit Care Med. Published 16 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →