Neuroanesthesia & neurocritical care
Quantitative analysis of early-stage EEG reactivity predicts awakening and recovery of consciousness in patients with severe brain injury
Main finding · Awakening in the ICUResult — go to the resultAdjusted odds ratio 0.89 95% CI 0.81–0.97Authors' conclusion
An early-stage quantitative EEG-R marker was independently associated with awakening and 3-month level of consciousness in patients with severe brain injury.
Study context
- Population
- Patients with severe brain injury requiring mechanical ventilation
- Participants
- 116 patients
- Outcome
- Awakening in the ICU, associated with quantitative EEG reactivity to auditory and nociceptive stimulations (11-lead EEG; power spectral density and phase-lag index)
Main finding
Awakening in the ICU
Adjusted odds ratio
0.89
95% CI 0.81–0.97
P = 0.02
Variation in delta-band phase-lag index connectivity after noise stimulation
aOR 0.89 (95% CI 0.81–0.97); P = 0.02
As reported in the abstract
- Patients who awoke in the intensive care unit (ICU)
- 86 (74%)
Observational data: associations, not effects.
Secondary outcomes
In-ICU mortality
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Variation in delta-band phase-lag index connectivity after noise stimulation | 1.08 (0.99–1.18) | P = 0.10 | |
| 0.512Adjusted odds ratio (log scale) |
| Outcome | Adjusted β | P value |
|---|---|---|
| 3-month CRS-R score · SE 0.075 | −0.16 | P = 0.048 |
Original publication
Quantitative analysis of early-stage EEG reactivity predicts awakening and recovery of consciousness in patients with severe brain injury. Br J Anaesth. Published 13 October 2022. doi:10.
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