ICU sedation, delirium & recovery
Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients: The R2D2-ICU Randomized Clinical Trial
Primary resultResult — go to the resultAdjusted mean difference 0.37 days 95% CI −0.71 to 1.46Authors' conclusion
In this randomized clinical trial, among adult patients receiving mechanical ventilation in the ICU, a low-use wrist-strap physical restraint strategy compared with a high-use strategy did not reduce days free of delirium or coma at 14 days.
Study context
- Population
- Adults on invasive mechanical ventilation started within the previous 6 hours, expected ≥48 hours of ventilation, 10 intensive care unit (ICUs) in France396 with primary outcome data
- Participants
- 405 adults
- Comparison
- Restrictive vs liberal wrist-strap physical restraint strategy
- Low-usen = 201
- High-usen = 204reference
- Primary endpoint
- Days alive without coma or delirium
- Follow-up
- First 14 days after randomization
Methodological detailsopen-label, multicentre (10 ICUs)
- Open-label
- Multicentre (10 ICUs)
Primary result
As reported in the abstract
Adjusted mean difference
0.37 days
95% CI −0.71 to 1.46
P = 0.51
By group
Low-use vs High-use
adjusted mean difference 0.37 days (95% CI −0.71 to 1.46); P = 0.51
Secondary outcomes
Day-90 mortality
Safety
Self-extubation
Original publication
Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients: The R2D2-ICU Randomized Clinical Trial. JAMA. Published 14 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →