Randomized Assessment of the Optimal Time Interval Between Programmed Intermittent Epidural Boluses When Combined With the Dural Puncture Epidural Technique for Labor Analgesia
An erratum to this article was published (Anesth Analg, 1 Oct 2023 ↗)
Authors' conclusion
The estimate of the PIEB optimal interval for effective analgesia after the DPE technique was comparable to that reported in previous studies when analgesia was initiated using a conventional epidural technique.
Study context
- Population
- Laboring parturients receiving dural puncture epidural (DPE) labor analgesia (15 mL ropivacaine 0.1% with sufentanil 0.5 μg/mL after 25-gauge Whitacre dural puncture), maintained with programmed intermittent epidural bolus (PIEB) 10 mL boluses93 maintained with PIEB
- Participants
- One hundred participants
- Comparison
- PIEB intervals of 35, 40, 45, 50 or 55 minutes after DPE initiation
- 35n = 19
- 40n = 19
- 45n = 17
- 50n = 19
- 55n = 19
- Primary endpoint
- Effective analgesia (no additional patient-controlled bolus during first stage of labor); EI50 and EI90 PIEB interval
- Follow-up
- First stage of labor
Methodological detailsdose-finding (interval-finding), probit regression
- Dose-finding (interval-finding)
- Probit regression
Primary result
As reported in the abstract
Effective PIEB analgesia
- EI50 52.5 minutes
- 52.5 (95% CI, 48.4-62.6)
- EI90 37.0 minutes
- 37.0 (95% CI, 28.4-40.9)
Original publication
Randomized Assessment of the Optimal Time Interval Between Programmed Intermittent Epidural Boluses When Combined With the Dural Puncture Epidural Technique for Labor Analgesia. Anesth Analg. Published 19 September 2022. doi:10.
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