Perioperative medicine & outcomes
A Randomized, Controlled Trial Evaluating Perioperative Risk-stratification and Risk-based, Protocol-driven Management After Elective Major Cancer Surgery
Authors' conclusion
Risk-based, protocol-driven management did not reduce the 30-day rate of DSC after elective major cancer surgery compared with usual management, nor did it improve postoperative health care utilization, HRQOL, or cancer outcomes.
Study context
- Population
- Adults scheduled for elective major cancer surgery738 + 732 analysed
- Participants
- 1,529 adults
- Comparison
- Intervention vs Usual management
- Interventionn = 738
- Usual managementn = 732reference
- Primary endpoint
- 30-day rate of DSC
- Follow-up
- 30 days
Methodological detailsstratified randomisation, Enrolment August 2014 to June 2020
- Stratified randomisation
- Enrolment August 2014 to June 2020
Primary result
As reported in the abstract
P = 0.65
Further findings
| Outcome | P value |
|---|---|
| Overall survival · median follow-up 48 monthsSimilar | P = 0.57 |
| Disease-free survival · median follow-up 48 monthsSimilar | P = 0.91 |
Complications, LOS, discharge home, health-related quality of life (HRQOL), readmission, antineoplastic therapy · 30, 60, or 90 days
- No differences between the study arms
Safety
Adverse events (including return to the OR) · 30 days
- No differences between the study arms
Original publication
A Randomized, Controlled Trial Evaluating Perioperative Risk-stratification and Risk-based, Protocol-driven Management After Elective Major Cancer Surgery. Ann Surg. Published 24 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →