Randomized Prospective Trial of Epidural Analgesia after Open Hepatectomy
Authors' conclusion
PCEA was safe following open hepatectomy and was associated with a small difference in pain with activity on POD 2 that did not reach our pre-specified definition of clinical significance.
Study context
- Population
- Patients undergoing elective open hepatectomyrandomised 2015–2020
- Participants
- 231 patients
- Comparison
- Patient-controlled epidural analgesia (PCEA) vs IV PCA after elective open hepatectomy
- PCEAn = 116
- IV PCAn = 115reference
- Primary endpoint
- Pain during ambulation (numeric rating scale (NRS)); powered to detect a clinically significant 2-point difference
- Follow-up
- POD 2
Methodological detailsprospective, nonblinded
- Prospective
- Nonblinded
Primary result
As reported in the abstract
NRS pain score during ambulation
PCEA
4.0
median
IV PCA
5.0
median
P < 0.001
Secondary outcomes
Secondary outcomes incl. pain at rest
- Similar between the study arms
Safety
Overall complications · no difference
P = 0.276
Epidural failure and epidural-related complications
- Epidural failure (n=4/116)
- 3%
- Epidural-related complications
- 0
Original publication
Randomized Prospective Trial of Epidural Analgesia after Open Hepatectomy. Ann Surg. Published 12 January 2024. doi:10.
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