Real‐world causal evidence for planned predictive enrichment in critical care trials: A scoping review
Authors' conclusion
Work is needed to harness the rich multiverse of critical care data and establish its utility in critical care RCTs.
Study context
- Population
- RCTs enrolling adult critically ill patients, reports published on or after 1 January 2018
- Participants
- 316 RCTs
- Outcome
- Use of causal evidence from secondary data for planned predictive enrichment
Methodological detailssystematic search of 10 general and speciality journals
- Systematic search of 10 general and speciality journals
Main finding
As reported in the abstract
- RCTs that used causal evidence from secondary data for planned predictive enrichment
- 0
Further findings
Intervention type
- Drug interventions
- 173 (55%)
- Management strategies
- 101 (32%)
- Devices
- 42 (13%)
Trial size and duration
- Median duration of enrolment, years (IQR)
- 2.2 (1.3-3.4)
- Trials randomising <1000 participants
- 83%
- Trials restricted to COVID-19 patients
- 36 (11%)
Early stopping
- Trials stopped early
- 55 (17%)
- Of these, used predefined rules
- 23 (42%)
- Commonest stopping reasons: futility, slow enrolment, safety concerns
Original publication
Real‐world causal evidence for planned predictive enrichment in critical care trials: A scoping review. Acta Anaesthesiol Scand. Published 30 August 2023. doi:10.
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