Reasons for death in patients receiving extracorporeal cardiopulmonary resuscitation (ECPR) for refractory out-of-hospital cardiac arrest
Authors' conclusion
Refractory shock was the leading cause of death among our cohort of ECPR patients, followed closely by neurological complications, while other causes were rare.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) patients who received ECPR and died during their index hospitalization152 died
- Participants
- 210 patients
- Primary endpoint
- Primary cause of death (five predefined categories)
Methodological detailsJanuary 2012 to December 2023; 1,219 OHCA patients admitted
- January 2012 to December 2023; 1,219 OHCA patients admitted
Primary result
As reported in the abstract
Primary cause of death
Refractory shock
75/152 patients, 49.3%
Neurological injury
69/152 patients, 45.3%
Rearrest
7/152 patients, 4.6%
Comorbidities
1/152 patients, 0.6%
Further findings
In-hospital mortality
- Died during index hospitalization
- 152 (72.3%)
Interrater agreement (Fleiss' kappa)
- Interrater agreement
- 0.81
Characteristics of deceased patients
- Median age, years
- 57
- Male
- 80.9%
- Median time to ECPR initiation, min (IQR)
- 62 (53-72)
Original publication
Reasons for death in patients receiving ECPR for refractory out-of-hospital cardiac arrest. Resuscitation. Published 16 April 2025. doi:10.
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