The Relationship Between Chronic Postoperative Pain and Circulating Inflammatory Biomarkers (CC-Chemokine Ligand 5, Adiponectin, and Resistin) After Fracture-Related Surgery in Pain Chronification
Authors' conclusion
Our explorative cytokine analysis uncovered an imbalance in serum cytokines and chemokines during the chronification process in patients who developed CPSP 1 year after surgically treated fractures. In particular, adiponectin and resistin were noted to be novel biomarkers for CPSP development.
Study context
- Population
- Patients with traumatic fractures requiring osteosynthesis
- Participants
- 30 patients
- Exposure
- Patients with vs without CPSP at 1 year after fracture-related surgery
- CPSPn = 12
- Outcome
- Serum cytokines, chemokines and adipocytokines (22, Luminex) in patients with vs without CPSP
- Follow-up
- D1, W6 and Y1 after surgery
Methodological detailsexploratory, serum cytokine profiling
- Exploratory
- Serum cytokine profiling
Main finding
As reported in the abstract
Serum cytokine levels, CPSP vs no-CPSP
- Resistin at Y1: CPSP 1.04 ± 1.04 vs no-CPSP 0.41 ± 0.31 pg/mL
- P < .001
- Adiponectin at Y1: CPSP 9.37 ± 8.23 vs no-CPSP 5.57 ± 2.75 μg/mL
- P = .008
- CCL5 at D1 higher in CPSP: MD 5.5 ng/mL (CI 1.7-9.3)
- P = .014
Observational data: associations, not effects.
Further findings
Correlation with pain intensity in CPSP patients · W6 and Y1
- Adiponectin r = 0.50
- P = 0.03
- CCL5 r = −0.50
- P = 0.03
Correlation of resistin with pain intensity, entire population · D1-Y1
- Resistin r = 0.34
- P < 0.001
Original publication
The Relationship Between Chronic Postoperative Pain and Circulating Inflammatory Biomarkers (CC-Chemokine Ligand 5, Adiponectin, and Resistin) After Fracture-Related Surgery in Pain Chronification. Anesth Analg. Published 25 March 2025. doi:10.
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