Remote Multicomponent Rehabilitation in Intensive Care Unit Survivors: A Randomized Clinical Trial
Primary result · EQ-5D-5L utility scoreResult — go to the resultAdjusted mean difference 0.04 95% CI −0.001 to 0.09Authors' conclusion
A 6-week, multicomponent, rehabilitation program did not improve health-related quality of life at 8 weeks after discharge in ICU survivors who required mechanical ventilation.
Study context
- Population
- Adults discharged from hospital within the last 12 weeks after intensive care unit (ICU) admission with mechanical ventilation ≥48 hours, 52 NHS hospitals in the UK3,705 screened
- Participants
- 429 adults
- Comparison
- 6-week remote multicomponent rehabilitation vs standard care
- Interventionn = 231
- Standard caren = 198reference
- Primary endpoint
- Health-related quality of life by EQ-5D-5L utility score (−0.285 to 1; minimum clinically important difference 0.08), linear regression adjusted for baseline covariates
- Follow-up
- 8 weeks
Methodological detailspragmatic, multicentre, assessor-blinded, December 2022 to November 2025
- Pragmatic
- Multicentre
- Assessor-blinded
- December 2022 to November 2025
Primary result
EQ-5D-5L utility score
Adjusted mean difference
0.04
95% CI −0.001 to 0.09
P = 0.05
By group
Intervention
0.69
mean · SD 0.26
Standard care
0.67
mean · SD 0.27
Intervention vs Standard care
adjusted mean difference 0.04 (95% CI −0.001 to 0.09); P = 0.05
As reported in the abstract
Secondary outcomes
- Intervention improved 4 of the 6 secondary outcomes: leg strength and exercise capacity, fatigue, anxiety, acceptability
- No change in perception of depression or illness
Safety
- Adverse events related to the intervention
- 4
- Serious events attributed to the intervention
- 0
Original publication
Remote Multicomponent Rehabilitation in Intensive Care Unit Survivors: A Randomized Clinical Trial. JAMA. Published 21 July 2026. doi:10.
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