Pediatric anesthesia & critical care

Respiratory Syncytial Virus and US Pediatric Intensive Care Utilization

JAMA Netw OpenPublished Retrospective cross-sectional study

An erratum to this article was published (JAMA Netw Open, 3 Mar 2025 ↗)

Authors' conclusion

The findings of this retrospective cross-sectional study of RSV and US pediatric intensive care utilization suggest that if 65% to 85% of eligible children received RSV prevention, an estimated 2.1% to 2.8% reduction in pediatric ICU encounters and an estimated 4.5% to 5.9% reduction in pediatric ICU days could be achieved.

Study context

Population
US children (aged >1 day and <18 years) admitted to an intensive care unit (ICU), January 1, 2017, to June 1, 2023
Participants
119,782 children · 53 hospitals
Exposure
ICU encounters with respiratory syncytial virus (RSV) vs without RSV
  • RSVn = 13,702
Outcome
ICU encounters with RSV and ICU encounters with RSV eligible for RSV prevention
Methodological detailsnational electronic health record database, Data from Oracle Cerner RealWorld Data
  • National electronic health record database
  • Data from Oracle Cerner RealWorld Data

Main finding

As reported in the abstract

ICU encounters with RSV

RSV

11.4%

13 702

RSV encounters eligible for prevention
38.6% (5217)
Eligible RSV encounters as share of total ICU encounters
4.4%

Observational data: associations, not effects.

Further findings

Positive pressure ventilation

P < 0.001

Vasoactive medications

P < 0.001

ICU days

ICU days accounted for by RSV encounters
21.1% (109 334)
RSV ICU days eligible for prevention
43.8% (47 888)
Eligible RSV ICU days as share of total ICU days
9.2%

Original publication

Respiratory Syncytial Virus and US Pediatric Intensive Care Utilization. JAMA Netw Open. Published 1 October 2024. doi:10.1001/jamanetworkopen.2024.40997

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