Resting-state brain functional connectivity in patients with chronic intractable pain who respond to spinal cord stimulation therapy
Authors' conclusion
For patients with intractable chronic pain, functional connectivity between the middle anterior cingulate cortex and precuneus/posterior cingulate cortex is a promising candidate biomarker to estimate responsiveness to spinal cord stimulation before treatment.
Study context
- Population
- Patients with intractable chronic pain undergoing spinal cord stimulation (SCS) trials
- Participants
- 29 patients
- Comparison
- Responder vs Non-responder
- Respondern = 14
- Non-respondern = 15reference
- Outcome
- Prediction of SCS responsiveness by resting-state functional connectivity (ROC analysis)
Performance
As reported in the abstract
Middle anterior cingulate cortex–precuneus/posterior cingulate cortex functional connectivity predicting SCS responsiveness
- Sensitivity
- 71%
- Specificity
- 87%
- AUC
- 0.814
- Prediction greater than chance
- P<0.001
Original publication
Resting-state brain functional connectivity in patients with chronic intractable pain who respond to spinal cord stimulation therapy. Br J Anaesth. Published 30 November 2024. doi:10.
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