Cardiac arrest & resuscitation
Rhythm-specific association of epinephrine with outcomes in non-shockable cardiac arrest: a nationwide propensity-matched study
Main finding · Association of epinephrine with ROSC by initial rhythmResult — go to the resultInteraction OR 0.60 95% CI 0.51–0.68Authors' conclusion
The association between epinephrine and ROSC was greater in patients with asystole than in those with PEA, although a statistically significant association was observed in both groups.
Study context
- Population
- Adult out-of-hospital cardiac arrest (OHCA) patients with non-shockable rhythms, Japanese Association for Acute Medicine OHCA registry, June 2014–December 2021
- Participants
- 58,977 patients
- Exposure
- Epinephrine vs no epinephrine, by initial rhythm
- Asystolen = 42,161
- Pulseless electrical activity (PEA)n = 16,816
- Outcome
- Association between epinephrine and ROSC by initial rhythm
Methodological detailstime-dependent propensity-score risk-set matching, nationwide registry
- Time-dependent propensity-score risk-set matching
- Nationwide registry
Main finding
As reported in the abstract
Association of epinephrine with ROSC by initial rhythm · 5 min after EMS contact
Interaction OR
0.60
95% CI 0.51–0.68
By group
Asystole
1.81
95% CI 1.57–2.07
OR of epinephrine for return of spontaneous circulation (ROSC)
PEA
1.43
95% CI 1.14–1.58
OR of epinephrine for ROSC
Asystole vs PEA
interaction OR 0.60 (95% CI 0.51–0.68)
Observational data: associations, not effects.
Further findings
30-day survival
- Similar trend observed
Favourable neurological outcome · 30 days
- No significant difference by initial rhythm
Original publication
Rhythm-specific association of epinephrine with outcomes in non-shockable cardiac arrest: a nationwide propensity-matched study. Resuscitation. Published 30 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →