ICU sedation, delirium & recovery
Risk factors for transitions and outcomes of subsyndromal delirium in the ICU: Post-hoc analysis of a prospective multicenter cohort study
Authors' conclusion
This study identified risk profiles and validated SSD as an intermediate prognostic condition, supporting early interventions to prevent delirium-associated harms.
Study context
- Population
- Critically ill adults screened with the Intensive Care Delirium Screening Checklist (ICDSC), excluding primary neurologic diagnosis or persistent coma168 delirium status unknown
- Participants
- 1,572 adults
- Comparison
- SSD vs delirium vs no delirium
- No deliriumn = 562
- SSD without deliriumn = 488
- SSD progressing to deliriumn = 180
- Delirium without prior SSDn = 174
- Unknown delirium statusn = 168
- Primary endpoint
- Risk factors for SSD progression and association with hospital mortality
Primary result
As reported in the abstract
Risk factors for SSD onset/progression and hospital mortality
Odds ratio (95 % CI)
SSD vs Deliriumhospital mortality
0.57(0.36–0.90)
SSD vs No deliriumhospital mortality; no significant difference
1.30(0.69–2.42)
Secondary outcomes
ICU LOS
- SSD shorter ICU stays than delirium but longer than no delirium
Original publication
Risk factors for transitions and outcomes of subsyndromal delirium in the ICU: Post-hoc analysis of a prospective multicenter cohort study. J Crit Care. Published 6 March 2025. doi:10.
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