Cardiac arrest & resuscitation

Sex- and Age-Based Disparities in Public Access Defibrillation, Bystander Cardiopulmonary Resuscitation, and Neurological Outcome in Cardiac Arrest

JAMA Netw OpenPublished Prospective cohort study

Main finding · Favorable neurological outcome, younger females vs males of same ageResult — go to the resultOdds ratio 1.19 95% CI 1.08–1.31

Authors' conclusion

Results of this study suggest a pattern of significant sex- and age-based differences in bystander CPR, public access defibrillation, and neurological outcomes in Japan.

Study context

Population
Patients with out-of-hospital cardiac arrest (OHCA) of cardiac origin witnessed by citizens and treated by EMS personnel, All-Japan Utstein Registry, 2005–2020median age 78 years
Participants
354,409 patients
Exposure
Females vs males, stratified by age
  • Femalesn = 136,520
Outcome
Favorable neurological outcome (Cerebral Performance Category 1 or 2)
Follow-up
30 days
Methodological detailspopulation-based, nationwide registry
  • Population-based
  • Nationwide registry

Main finding

As reported in the abstract

Favorable neurological outcome, younger females vs males of same age

Odds ratio

1.19

95% CI 1.08–1.31

Females vs Males
OR 1.19 (95% CI 1.08–1.31)

Observational data: associations, not effects.

Secondary outcomes

Public access defibrillation

P < 0.001

Favorable neurological outcome by intervention (younger females, nonfamily-witnessed OHCA subgroup)

OR (95% CI)
Public access defibrillation3.51 (2.34–5.27)
Bystander CPR1.62 (1.20–2.22)

Public access defibrillation and bystander cardiopulmonary resuscitation (CPR) (younger patients)

Younger females had a lower rate of public access defibrillation and bystander CPR than males

Original publication

Sex- and Age-Based Disparities in Public Access Defibrillation, Bystander Cardiopulmonary Resuscitation, and Neurological Outcome in Cardiac Arrest. JAMA Netw Open. Published 3 July 2023. doi:10.1001/jamanetworkopen.2023.21783

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