Sex differences in the association between bystander cardiopulmonary resuscitation (CPR) and survival for Out-of-Hospital cardiac arrest
Authors' conclusion
For OHCA, bystander CPR was associated with higher survival in women and men. However, as currently practiced, the association between bystander CPR and higher survival was weaker for women as compared with men.
Study context
- Population
- Adults with non-traumatic out-of-hospital cardiac arrest (OHCA), US OHCA registry, 2013–2020
- Participants
- 420,671 adults
- Exposure
- Bystander CPR vs no bystander CPR, by sex
- Womenn = 151,145
- Menn = 269,526
- Outcome
- Favorable neurological survival
Methodological detailsregistry-based, Multivariable logistic regression with sex × bystander CPR interaction, adjusted for patient and arrest characteristics
- Registry-based
- Multivariable logistic regression with sex × bystander CPR interaction, adjusted for patient and arrest characteristics
Main finding
As reported in the abstract
Favorable neurological survival, bystander CPR vs none, by sex
Adjusted odds ratio (95 % CI)
Bystander CPR (women) vs No bystander CPR (women)women
1.33(1.27–1.39)
Bystander CPR (men) vs No bystander CPR (men)men
1.55(1.51–1.61)
%
- Favorable neurological survival with bystander CPR
- 11.4
- Favorable neurological survival without bystander CPR
- 5.6
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Adjusted OR (95 % CI) | |
|---|---|---|
| Survival to discharge, bystander CPR vs none, by sexBystander CPR (women) vs No bystander CPR (women) · women | 1.21 (1.16–1.26) | |
| Survival to discharge, bystander CPR vs none, by sexBystander CPR (men) vs No bystander CPR (men) · men | 1.43 (1.39–1.47) | |
| 0.512Adjusted odds ratio (log scale) |
Rate of layperson bystander CPR
%
- Survival to discharge, bystander CPR vs none, by sex — Survival to discharge with bystander CPR
- 13.1
- Survival to discharge, bystander CPR vs none, by sex — Survival to discharge without bystander CPR
- 7.3
- Survival to discharge, bystander CPR vs none, by sex: interaction p < 0.001
Rate of layperson bystander CPR
- Similar between women and men
Original publication
Sex differences in the association between bystander CPR and survival for Out-of-Hospital cardiac arrest. Resuscitation. Published 24 September 2022. doi:10.
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