Skeletal muscle relaxant for the treatment of fibromyalgia: a systematic review and meta-analysis of randomized controlled trials
Pooled resultResult — go to the resultSMD −0.24 95% CI −0.32 to −0.15Authors' conclusion
Moderate quality evidence showed that muscle relaxants were associated with a small reduction in pain intensity for patients with fibromyalgia.
Study context
- Population
- Patients with fibromyalgia
- Participants
- 1,851 patients · 14 randomized controlled trials (RCTs)
- Comparison
- Skeletal muscle relaxants vs placebo/active analgesics
- Outcome
- Pain intensity (SMD in pain scores)
Methodological detailsGRADE rating, Cochrane risk of bias assessment
- GRADE rating
- Cochrane risk of bias assessment
Pooled result
As reported in the abstract
SMD
−0.24
95% CI −0.32 to −0.15
P < 0.001
Muscle relaxants vs Placebo/active analgesics
SMD −0.24 (95% CI −0.32 to −0.15); P < 0.001
Further pooled results
Depression, fatigue and sleep quality
- Small but statistically significant improvements with muscle relaxants
Safety
Overall adverse effects, fatigue, abnormal taste, drug withdrawal due to adverse effects
- Increased incidence with muscle relaxants
Original publication
Skeletal muscle relaxant for the treatment of fibromyalgia: a systematic review and meta-analysis of randomized controlled trials. Reg Anesth Pain Med. Published 11 November 2024. doi:10.
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