Spinal cord perfusion pressure correlates with breathing function in patients with acute, cervical traumatic spinal cord injuries: an observational study
Authors' conclusion
After acute, cervical traumatic spinal cord injuries, breathing function depends on the SCPP. SCPP 80-90 mmHg correlates with optimum diaphragmatic and intercostal muscle function.
Study context
- Population
- Patients with acute cervical traumatic spinal cord injuries106 ultrasound exams · 198 EDI recordings
- Participants
- 13 vs 8
- Exposure
- Breathing function vs spinal cord perfusion pressure (SCPP)
- Cervical TSCIn = 13
- Without cervical TSCIn = 8reference
- Outcome
- Breathing function (diaphragmatic EMG via EDI nasogastric tube; ultrasound of diaphragm and intercostal muscles) in relation to SCPP
Main finding
As reported in the abstract
Breathing function vs SCPP in TSCI
- Quiet breathing: low SCPP (< 60 mmHg) associated with reduced EDI-peak and EDI-min, which increased then plateaued at SCPP 60-100 mmHg
- Diaphragmatic thickening fraction (quiet and deep breathing) vs SCPP: inverted-U, peak at SCPP 80-90 mmHg
- Diaphragmatic excursion during quiet breathing did not correlate with SCPP; during deep breathing inverse-U, peak at SCPP 80-90 mmHg
- Intercostal thickening fraction vs SCPP: inverted-U, normal function at SCPP 80-100 mmHg; failure of upper and middle intercostals to contract during inspiration (abdominal breathing) at SCPP < 80 or > 100 mmHg
Observational data: associations, not effects.
Original publication
Spinal cord perfusion pressure correlates with breathing function in patients with acute, cervical traumatic spinal cord injuries: an observational study. Crit Care. Published 20 September 2023. doi:10.
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