Statistical significant results in regional anesthesia randomized controlled trials: Investigating prevalence, associated factors and implications – A systematic review
Authors' conclusion
A high proportion of RA RCTs report statistically significant results, and these outcomes are associated with study design and comparator choice.
Study context
- Population
- Regional anesthesia (RA) randomized controlled trials (RCTs) published in 136 journals of the "Anesthesia and Pain Medicine" category (Scopus CiteScore)RA RCTs of 4524 articles
- Participants
- 1,079 participants
- Outcome
- Prevalence of statistically significant results (primary outcome p < 0.05) in RA RCTs
Methodological detailsmeta-research, logistic regression
- Meta-research
- Logistic regression
Pooled result
As reported in the abstract
Not statistically significant primary outcome
RCTs reporting not statistically significant results
241
22.3%
Further pooled results
Factors associated with statistically significant findings (logistic regression)
| OR (95% CI) | ||
|---|---|---|
| Studies focused on RA techniques | 2.28 (1.12–4.63) | |
| Studies of pediatric populations | 3.39 (1.19–9.66) | |
| Studies not receiving funding | 0.67 (0.46–0.98) | |
| 0.10.31310Odds ratio (log scale) |
- Factors associated with statistically significant findings (logistic regression) — Model performance AUC
- 0.690
Study characteristics
- Monocentric studies
- 95.8%
- Non-active comparators
- 40.4%
Original publication
Statistical significant results in regional anesthesia randomized controlled trials: Investigating prevalence, associated factors and implications – A systematic review. J Clin Anesth. Published 17 February 2026. doi:10.
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