Perioperative medicine & outcomes
Surgical exposure and biological aging: A population-based study from the UK Biobank
Authors' conclusion
Cumulative surgical exposure was associated with modest but detectable differences in PhenoAge acceleration, with associations varying according to surgical burden, surgical timing, and baseline physiological reserve.
Study context
- Population
- UK Biobank participantsup to
- Participants
- 472,279 participants
- Exposure
- Number of surgeries within 1, 3 and 5 years before baseline
- Outcome
- Biological aging: PhenoAge acceleration and leukocyte telomere length (LTL)
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
As reported in the abstract
β
0.46 years
95% CI 0.43–0.49; P < 0.001
Each additional surgery within 1 year
β
0.26 years
95% CI 0.24–0.27; P < 0.001
Each additional surgery within 3 years
β
0.20 years
95% CI 0.19–0.21; P < 0.001
Each additional surgery within 5 years
Observational data: associations, not effects.
Further findings
Leukocyte telomere length (LTL) per additional surgery
| β (SD) (95% CI) | |
|---|---|
| Each additional surgery within 1 yearFully adjusted | - 0.002 (−0.009 to 0.006) |
| Each additional surgery within 3 yearsFully adjusted | −0.003 (−0.007 to 0.001) |
| Each additional surgery within 5 yearsFully adjusted | - 0.002 (−0.005 to 0.001) |
PhenoAge acceleration by surgical stress and by frailty/comorbidity (subgroup)
- Stronger association with moderate to high stress surgeries
- P for heterogeneity < 0.001
- Stronger association with frailty or greater comorbidity burden
- P for interaction < 0.001
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →