Safety, quality & education

The applications of ChatGPT and other large language models in anesthesiology and critical care: a systematic review

Can J AnaesthPublished Systematic review

Authors' conclusion

While LLMs are not yet equipped to fully assist physicians in anesthesiology and critical care, they have significant potential, and their capabilities are rapidly improving.

Study context

Population
Studies investigating large language models (LLMs) (GPT-4, GPT-3.5, Google Bard [now Gemini], LLaMA, others) in anesthesiology or critical care45 papers included of 480
Methodological detailsPRISMA, Searched PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science from inception until 1 August 2024
  • PRISMA
  • Searched PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science from inception until 1 August 2024

Pooled result

As reported in the abstract

  • Applications in 4 segments: ICU, patient education, medical education, perioperative care
  • LLMs, especially newer models, promising in predicting clinical scores, navigating simple clinical scenarios, managing preoperative anxiety
  • Performance below clinician level in predicting outcomes, complex clinical scenarios (i.e., airway management), board examinations, generating patient-directed documents; newer models better than older ones

Original publication

The applications of ChatGPT and other large language models in anesthesiology and critical care: a systematic review. Can J Anaesth. Published 16 June 2025. doi:10.1007/s12630-025-02973-9

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