Perioperative medicine & outcomes
The Association Between Endothelial Biomarkers and Intravascular Albumin Loss After Major Abdominal Surgery—An Exploratory Pilot Study
Authors' conclusion
A positive correlation between increased albumin disappearance from the blood (k) and endothelial biomarkers was seen. A multi-biomarker model was constructed with significant correlation to k.
Study context
- Population
- Patients undergoing major open pancreatic surgery at Rigshospitalet, Copenhagen, Denmark
- Participants
- 10 patients
- Outcome
- Apparent disappearance rate (k) of 125I labeled HSA
- Follow-up
- First five postoperative days
Methodological detailsexploratory
- Exploratory
Main finding
As reported in the abstract
All patients
0.9
mean · 95% CI 0.8-1.1%/h · %/h
Secondary outcomes
Transcapillary escape rate (TER) of 125I labeled human serum albumin (HSA) · first postoperative hours
- Mean TER after surgery
- 6.6%/h (95% CI 3.8-9.3%/h)
Changes in endothelial biomarkers (syndecan-1, thrombomodulin, E-selectin, PECAM, VEGFR-1) · first five postoperative days
- Largest pre- to post-surgery change: Syndecan-1 increase, all patients
- 145%
- Large variation in all endothelial biomarker changes
Correlation between k and endothelial biomarkers (Spearman's rho)
- Positive correlation to k for all endothelial biomarkers except VEGFR-1 (only significant for thrombomodulin)
Weighted risk model for increased k from selected endothelial markers
- R2
- 0.586
- P
- P = 0.009
Original publication
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