The association between epidural labour analgesia and postpartum depression: a randomised controlled trial
Authors' conclusion
We found no significant difference in the risk of postpartum depression between patients who received epidural labour analgesia and those who utilised non-epidural analgesic modalities.
Study context
- Population
- Women aged 21–50 years with a singleton fetus ≥ 36 weeks gestation773 analysed
- Participants
- 881 women
- Comparison
- Epidural vs non-epidural labour analgesia
- Epiduraln = 441
- Non-epiduraln = 440reference
- Primary endpoint
- Postpartum depression (Edinburgh Postnatal Depression Scale score ≥ 13)
- Follow-up
- 6-10 weeks following delivery
Methodological detailsblinded outcome assessment, modified intention-to-treat and per-protocol analyses
- Blinded outcome assessment
- Modified intention-to-treat and per-protocol analyses
Primary result
Postpartum depression
Adjusted risk difference
1.6
95% CI −3.0-6.3%
P = 0.49
Events by treatment group
Epidural vs Non-epidural
adjusted risk difference 1.6 (95% CI −3.0-6.3%); P = 0.49
As reported in the abstract
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The association between epidural labour analgesia and postpartum depression: a randomised controlled trial. Anaesthesia. Published 21 November 2023. doi:10.
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