Cardiac arrest & resuscitation
The association of early naloxone use with outcomes in non-shockable out-of-hospital cardiac arrest
Primary result · ROSC at ED arrivalResult — go to the resultAdjusted odds ratio 2.14 95% CI 1.18–3.88Authors' conclusion
Patients with initial non-shockable OHCA who received law enforcement or EMS naloxone prior to IV/IO access attempts had higher adjusted odds of ROSC at any time, ROSC at ED arrival, survival to admission, survival to discharge, and good neurologic outcome.
Study context
- Population
- Non-traumatic out-of-hospital cardiac arrest (OHCA) with initial non-shockable rhythm, emergency medical services (EMS)-treated, Portland, Oregon metropolitan region, 2018–2021
- Participants
- 1,807 participants
- Comparison
- Naloxone before IV/IO access vs no early naloxone
- Naloxonen = 57
- Primary endpoint
- ROSC at emergency department (ED) arrival
Methodological detailsmultivariable logistic regression
- Multivariable logistic regression
Primary result
As reported in the abstract
Adjusted odds ratio
2.14
95% CI 1.18–3.88
Naloxone vs No early naloxone
aOR 2.14 (95% CI 1.18–3.88)
Secondary outcomes
| Outcome | aOR (95% CI) | |
|---|---|---|
| ROSC at any time | 2.14 (1.20–3.81) | |
| Survival to admission | 2.86 (1.60–5.09) | |
| Survival to hospital discharge | 4.41 (1.78–10.97) | |
| Good neurologic outcome (CPC ≤2 at discharge) | 4.61 (1.74–12.19) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Original publication
The association of early naloxone use with outcomes in non-shockable out-of-hospital cardiac arrest. Resuscitation. Published 6 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →