The cost-effectiveness of mild hypercapnia after out-of-hospital cardiac arrest: a health economic evaluation alongside the TAME study
Authors' conclusion
This analysis found that the cost-effectiveness of mild hypercapnia is highly uncertain when compared with normocapnia in adult patients following OHCA, with no significant differences in either costs or outcomes.
Study context
- Population
- Adults resuscitated after of hospital cardiac arrest (OHCA), 63 intensive care units (ICUs) in 17 countries
- Participants
- 1,586 adults · 63 ICUs · 17 countries
- Comparison
- Mild hypercapnia vs targeted normocapnia
- Primary endpoint
- Cost per QALY
- Follow-up
- 6 months
Methodological detailspre-specified, prospective, healthcare perspective, 6-month time horizon, multicentre
- Pre-specified
- Prospective
- Healthcare perspective
- 6-month time horizon
- Multicentre
Primary result
As reported in the abstract
Costs, QALYs and incremental net monetary benefit
- No significant differences in costs or quality-adjusted life year (QALYs) between groups
- Incremental net monetary benefit not significant at willingness-to-pay $50,000 per QALY; 95 % CI includes negative and positive values
Original publication
The cost-effectiveness of mild hypercapnia after out-of-hospital cardiac arrest: a health economic evaluation alongside the TAME study. Resuscitation. Published 30 October 2025. doi:10.
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