The Effect of Cryotherapy Application on Postoperative Pain: A Systematic Review and Meta-analysis
Authors' conclusion
Cryotherapy is a pragmatic, noncostly intervention that reduces postoperative pain and opioid consumption with no effect on SSI rate or hospital LOS.
Study context
- Population
- Adults after surgery with closed incisions
- Participants
- 3,425 adults · 51 RCTs
- Comparison
- Cryotherapy over closed surgical incisions vs no cryotherapy
- Outcome
- Postoperative pain
Methodological detailsrandom effects meta-analyses, duplicate selection, extraction and risk of bias appraisal
- Random effects meta-analyses
- Duplicate selection, extraction and risk of bias appraisal
Pooled result
As reported in the abstract
Cryotherapy vs No cryotherapySMD (95% CI)
POD 1; I² = 74%
−0.50(−0.71 to −0.29)
POD 2; I² = 83%
−0.63(−0.91 to −0.35)
Further pooled results
| Outcome | MD (95% CI) | |
|---|---|---|
| Opioid consumption (morphine milliequivalents)I² = 96% · moderate certainty of evidence | −7.43 (−12.42 to −2.44) | |
| Opioid consumption (morphine milliequivalents/kg)I² = 99% · moderate certainty of evidence | −0.89 (−1.45 to −0.33) | |
| −15−10−505Difference (linear scale) |
Hospital length of stay (LOS)
- Cryotherapy does not affect hospital LOS
- Low certainty evidence
Safety
Surgical site infection (SSI)
- Cryotherapy does not affect rate of SSI
- Low certainty evidence
Original publication
The Effect of Cryotherapy Application on Postoperative Pain: A Systematic Review and Meta-analysis. Ann Surg. Published 10 January 2023. doi:10.
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