Pediatric anesthesia & critical care
The effect of intraoperative methadone on postoperative opioid requirements in children undergoing orchiopexy: A randomized clinical trial
Primary result · Opioid requirement in the PACUResult — go to the resultMean difference −0.24 95% CI −0.03 to −0.47Authors' conclusion
A single dose of intraoperative methadone reduces short-term postoperative opioid requirements in children after orchiopexy for nondescended testes but prolongs the duration of their stay in the post-anesthesia care unit.
Study context
- Population
- Children aged <5 years undergoing orchiopexy for undescended testis60 completed
- Participants
- 68 children
- Comparison
- Single intraoperative dose of methadone vs isotonic saline
- Methadonen = 29
- Placebon = 31reference
- Primary endpoint
- Opioid requirements in the PACU (first primary outcome); pain intensity in the PACU
Methodological detailsdouble-blind, placebo-controlled, Follow-up 4 days
- Double-blind
- Placebo-controlled
- Follow-up 4 days
Primary result
Opioid requirement in the PACU
Mean difference
−0.24
95% CI −0.03 to −0.47
P = 0.037
Events by treatment group
Methadone
0.17
5 of 29
Placebo
0.42
13 of 31
As reported in the abstract
Secondary outcomes
| Outcome | Methadone | Placebo | Mean difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Pain intensity in the PACU: FLACC score ≥5 (second primary outcome) | — not stated in the abstract | 0.32 (95% CI 0.16–0.49) | −0.15 (−0.36 to 0.06) | P = 0.179 | |
| −0.4−0.200.2Difference (linear scale) |
— not stated in the abstract
Events
| Outcome | Methadone | Placebo |
|---|---|---|
| Woke up due to pain the first night after surgery · first postoperative night | 1 | 7 |
PACU LOS
- Longer PACU stay in the Methadone group
Other secondary outcomes (desaturation, time to discharge readiness, sleep, pain and opioid requirements at home)
- No differences between the two groups
Original publication
The effect of intraoperative methadone on postoperative opioid requirements in children undergoing orchiopexy: A randomized clinical trial. Paediatr Anaesth. Published 22 September 2024. doi:10.
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