The effect of Neurokinin-1 receptor antagonists on postoperative pain: A meta-analysis of randomized controlled trials
Pooled resultResult — go to the resultMD −0.62 95 % CI −0.91 to −0.32Authors' conclusion
Preoperative single-administration of NK-1 antagonists reduces postoperative pain.
Study context
- Population
- Surgical patients (hospitals)
- Participants
- 1,959 patients · 13 randomized controlled trials (RCTs)
- Comparison
- Preoperative NK-1 antagonists vs placebo or standard care
- Outcome
- Pain (0-10 numeric scale)
- Follow-up
- 2 h after surgery
Pooled result
As reported in the abstract
MD
−0.62
95 % CI −0.91 to −0.32
P < 0.001
NK-1 antagonists vs Placebo or standard care
MD −0.62 (95 % CI −0.91 to −0.32); P < 0.001
Further pooled results
| Outcome | MD (95 % CI) | P value | |
|---|---|---|---|
| Postoperative pain · 24 hn = 9 studies; I2 = 86 % | −0.65 (−1.22 to −0.09) | P = 0.02 | |
| −1.5−1−0.500.5Difference (linear scale) |
Postoperative pain · 48 h
- Not reduced 48 h after surgery
Morphine equivalent consumption
- Similar in the two groups
Original publication
The effect of Neurokinin-1 receptor antagonists on postoperative pain: A meta-analysis of randomized controlled trials. J Clin Anesth. Published 8 February 2025. doi:10.
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